The movie ‘Run’ is loosely based on a true story of how a group of runners ran 261 marathons in 261 days to raise awareness for the alarming number of children with trisomies like Down Syndrome. The word ‘trigoxin’ comes up many times in the book Run and this article will explain what trigoxin is and why people run in marathons to raise money for children with trisomies like Down syndrome.

What is Trigoxin?

Trigoxin is an antibiotic used to treat certain bacterial infections in both children and adults. It works by inhibiting certain bacterial enzymes, making it harder for the bacteria to make the proteins which help them survive and grow. This is a relatively new treatment, which was approved by the FDA in 2006, and has only been around for about 10 years. The bacteria which trigoxin is used to treat include E. coli, Klebsiella, Staphylococcus, and Enterobacter. Trigoxin is sold under the brand name Zosyn, and is a sulfa-based antibiotic. It is given intravenously, taken by mouth, and applied to the skin. It is available as a syrup, but is often mixed with water and injected into the muscle.

Why Run a Marathon to Raise Money for Trisomies?

People with Down syndrome are born with the genetic condition of Trisomy 21 (also known as Down Syndrome). This is an extra copy of chromosome 21, which normally has genes related to humans and other animals. People with Down syndrome usually have short stature and may have some health problems including learning difficulties, cleft palate, heart defects, and low muscle tone. Because of more than 600 genetic abnormalities, no two people with Down syndrome are exactly the same. Some may have increased risk for serious health problems including cancer, blindness, hearing loss and mental retardation. In fact, their risk of death is as high (or higher) than that of the general population. These are the reasons why many people with Down syndrome and their families have chosen to raise money for children with Trisomy 21 through marathons.

How Many Trisomies are There?

There are approximately 1,000 known genetic disorders. The most prevalent are Down Syndrome, Edwards Syndrome, and Patau Syndrome. People with trisomies A through D can have a miscarriage or an abortion during pregnancy, and have a 25% chance of delivering a baby with the extra chromosome. People with trisomies E through Z have a genetic abnormality that is not known to cause any symptoms. In case of trisomies A through D, extra chromosome causes health problems such as low IQ, poor muscle tone, heart problems, and characteristic facial features. People with trisomy 21 (Down Syndrome) usually have a short life expectancy. They often have learning disabilities and are prone to health problems like blindness, deafness, heart defects, and diabetes.

Facts and Figures

There are currently more than 1,800 registered charity running groups in the USA. Every year, $34.2 billion is given to charities. About 85% of people who give to charity are satisfied with their decision. About 10% of the world’s population is involved in charity fundraising. Chronic diseases cost the USA $1.9 trillion every year.

The Story of the Runners and the Marathons

A team of runners, led by Brian McCluskey, set out to run 100 marathons in 100 days for charity. Prior to the start of the project, the runners began to research their chosen cause and study the science behind Down Syndrome. They also created a profound movie and book to educate people about the condition. The runner’s team included Brian McCluskey, who was diagnosed with Down Syndrome; Mike Cuellar, a high school history teacher and coach who works with special needs students; Brian Koller, a lawyer with a specialty in intellectual disability law; and Cindy Brown, an occupational therapist and volunteer with Special Olympics. The runners contacted various organizations to ask them to endorse their campaign, but they were turned down by every single one. The runners were annoyed by this discrimination and decided to do something about it.


People with trisomies like Down Syndrome come with a set of challenges that need to be addressed sensitively. The challenges include intellectual disability, health issues, and a shortened life expectancy. People with Down Syndrome face a multitude of challenges throughout their life. Some of these challenges include intellectual disability, health issues, and a shortened life expectancy. People with Down Syndrome are often also denied access to healthcare and education because of their condition. These challenges need to be addressed sensitively and the best way to do so is by raising awareness and money for research. The runners from ‘Run’ did exactly that, and hopefully you enjoyed the movie as much as they did.

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